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Q3(e):
Indicate whether the following statements are true or false : (e) Glucose is actively reabsorbed in the proximal convoluted tubule.

Solution :

Step 1: Analyzing the Physiological Statement

The statement posits that glucose is actively reabsorbed in the proximal convoluted tubule (PCT). To evaluate this, we must analyze the transport mechanisms governing solute recovery in the nephron.

Step 2: Theoretical Foundation of Renal Reabsorption

Reabsorption in the PCT is a highly selective process. The proximal convoluted tubule is responsible for the reabsorption of approximately $100\%$ of filtered glucose, amino acids, and the majority of electrolytes under normal physiological conditions [Per the principle of selective reabsorption in the nephron].

Step 3: Mechanism of Glucose Transport

Glucose reabsorption does not occur via simple diffusion because the concentration of glucose in the tubular fluid is typically lower than in the peritubular capillary blood. Therefore, the process must occur against the concentration gradient:

  • Secondary Active Transport: Glucose is transported across the apical membrane (luminal side) of the PCT epithelial cells by Sodium-Glucose Linked Transporters (SGLTs). This utilizes the electrochemical gradient of $Na^+$ established by the $Na^+/K^+$-ATPase pump located on the basolateral membrane [Reference: Active Transport Mechanism].
  • Facilitated Diffusion: Once inside the PCT cell, glucose moves down its concentration gradient into the interstitial fluid (and subsequently the blood) through GLUT transporters (glucose uniporters) on the basolateral membrane.

Step 4: Visualizing the PCT Transport Mechanism

Lumen (Tubular Fluid) Peritubular Capillary Glucose SGLT (Active) GLUT (Passive)

Step 5: Logical Deduction

Since the transport of glucose across the apical membrane requires coupling with the $Na^+$ gradient maintained by active metabolic expenditure ($Na^+/K^+$-ATPase), the process is classified as active reabsorption.

Conclusion: The statement "Glucose is actively reabsorbed in the proximal convoluted tubule" is True.

Final Solution: True. The process involves secondary active transport mediated by SGLT proteins at the apical membrane of the proximal convoluted tubule cells.


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