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Q3(b):
Indicate whether the following statements are true or false : (b) ADH helps in water elimination, making the urine hypotonic.

Solution :

Analysis of the Statement

The statement provided is: "ADH helps in water elimination, making the urine hypotonic." To determine its veracity, we must evaluate the physiological function of Antidiuretic Hormone (ADH), also known as Vasopressin.

Step 1: Theoretical Mechanism of ADH

ADH is synthesized by the hypothalamus and released by the posterior pituitary gland. Its primary role is to regulate blood osmolarity and volume. It acts on the distal convoluted tubules (DCT) and, most significantly, the collecting ducts of the nephron [Per the mechanism of hormonal regulation of kidney function].

Step 2: Assessing Water Permeability

ADH functions by stimulating the insertion of water channel proteins called aquaporins into the apical membranes of the epithelial cells in the collecting ducts. This process drastically increases the permeability of these ducts to water. Consequently, water is reabsorbed from the tubular filtrate back into the hypertonic medullary interstitium via osmosis [By the principle of Osmotic Gradient].

Step 3: Evaluating the Impact on Urine Concentration

When ADH is present and active:

  • Water is reclaimed from the filtrate into the bloodstream.
  • The remaining tubular fluid becomes highly concentrated (hypertonic).
  • The volume of excreted urine decreases.
Conversely, a hypotonic urine is produced only in the absence of ADH, where water remains in the tubule and is excreted from the body [Per the physiological feedback loops for fluid homeostasis].

Step 4: Logical Comparison

Feature Actual Biological Effect Statement's Claim
Water Movement Reabsorption (Retention) Elimination
Urine Tonicity Hypertonic (Concentrated) Hypotonic (Dilute)

Visualization of the Collecting Duct Mechanism

Collecting Duct Lumen Hâ‚‚O Reabsorption ADH Effect

Final Solution: The statement is False. ADH facilitates the reabsorption of water, which results in the production of hypertonic (concentrated) urine, not hypotonic urine.


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