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Q12(d):
Fill in the gaps : (d) A healthy adult human excretes (on an average) _______ gm of urea/day.

Solution :

Step 1: Identifying the Metabolic Context

In human physiology, the liver is the primary site of urea synthesis through the Ornithine Cycle (also known as the Urea Cycle). Ammonia ($NH_3$), which is highly toxic, is converted into urea ($NH_2CONH_2$) to facilitate safe excretion via the kidneys. The quantity of urea excreted is intrinsically linked to the dietary intake of proteins and the metabolic rate of the individual. [Per Guyton and Hall, Textbook of Medical Physiology]

Step 2: Quantitative Analysis of Urea Excretion

A healthy adult human on a standard diet typically catabolizes proteins, resulting in the production of nitrogenous waste. Clinical physiological data indicates that the daily excretion of urea in urine is significantly dependent on protein consumption. Standard biological benchmarks establish the following parameters:

Metric Value
Average Protein Intake $70 - 100$ grams/day
Average Urea Excretion $25 - 30$ grams/day

Step 3: Justification and Calculation

The calculation is based on the stoichiometry of nitrogen metabolism. The excretion of approximately $25$ to $30$ grams of urea per day serves to maintain nitrogen balance, ensuring that the blood urea nitrogen (BUN) levels remain within the normal range of $7 - 20$ $mg/dL$. Deviation from this range indicates potential renal impairment or metabolic abnormalities. [Reference: NCERT Biology Class 11, Chapter 19: Excretory Products and Their Elimination]

Visual Representation of Urea Molecule

NHâ‚‚ C=O NHâ‚‚ Chemical Formula: CHâ‚„Nâ‚‚O

Final Solution: A healthy adult human excretes (on an average) 25-30 gm of urea/day.


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