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Q3(d):
Indicate whether the following statements are true or false : (d) Henle’s loop plays an important role in concentrating the urine.

Solution :

Statement Analysis

The statement is: "Henle’s loop plays an important role in concentrating the urine."

Verdict: True

Scientific Justification & Physiological Mechanism

The Loop of Henle is essential for the process of urine concentration in mammals, facilitating the production of hypertonic urine through a mechanism known as the Countercurrent Multiplier System.

1. Structural Segregation of Permeability:

  • Descending Limb: Highly permeable to water due to high concentrations of aquaporins but nearly impermeable to electrolytes [Per the Osmotic Gradient Theory]. As the filtrate moves down into the hypertonic medullary interstitium, water exits the tubule via osmosis, resulting in the concentration of the tubular fluid.
  • Ascending Limb: Impermeable to water but highly permeable to solutes ($Na^+$, $K^+$, $Cl^-$). In the thin segment, solutes move passively; in the thick segment, they are actively transported out into the interstitium [Per Active Transport of Electrolytes].

2. Countercurrent Multiplication:

The continuous flow of filtrate in opposite directions in the two limbs creates a gradient of osmolarity in the renal medulla, increasing from approximately $300\ mOsm/L$ in the cortex to $1200\ mOsm/L$ in the inner medulla. This gradient is the driving force for water reabsorption in the collecting duct.

Visual Representation of Countercurrent Mechanism

Water Out Salts Out Descending Ascending Osmolarity increases towards medulla base

Evidence-Based Synthesis

By establishing this osmotic gradient, the Loop of Henle ensures that when the filtrate reaches the collecting duct, antidiuretic hormone (ADH/Vasopressin) can trigger water reabsorption, thereby producing concentrated (hypertonic) urine and conserving body water [Reference: Guyton and Hall, Textbook of Medical Physiology].

Final Solution: The statement is True. The Henle’s loop creates a medullary osmotic gradient via countercurrent multiplication, which is indispensable for the concentration of urine.


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