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Q4:
What is $G_0$ (quiescent phase) of cell cycle?

Solution :

Theoretical Definition of the $G_0$ Phase

The $G_0$ phase, colloquially known as the quiescent phase, represents a state in which cells exit the active cell cycle (post-mitosis) and enter a period of metabolic activity without undergoing division. This state is regulated by specific extracellular signals and intracellular checkpoints [Per the Cell Cycle Regulation Model].

Step 1: Mechanism of Entry into Quiescence

Following the completion of mitosis ($M$ phase), cells enter the $G_1$ phase. If the environmental conditions—such as nutrient availability, growth factors, or cell density—are suboptimal, the cell does not pass the Restriction Point (R-point). Instead, it transitions into the $G_0$ phase. During this transition, the expression of cyclins and cyclin-dependent kinases ($CDKs$) required for the $S$ phase is downregulated [By the Retinoblastoma Protein ($pRb$) pathway].

Step 2: Physiological and Metabolic Characteristics

While the cell is not dividing, it remains biologically functional. The $G_0$ phase is characterized by the following criteria:

  • Metabolic Activity: The cell maintains homeostatic functions, protein synthesis, and respiration.
  • DNA Content: The DNA remains in a $2C$ state (diploid), as the cell has not yet entered the $S$ phase ($DNA$ synthesis).
  • Reversibility: Depending on the cell type, this state may be permanent (e.g., neurons) or temporary (e.g., hepatocytes or lymphocytes).

Step 3: Schematic Representation of the Cell Cycle

S Phase G2 G1 G0 Exit

Step 4: Comparative Analysis of Cell Fate

Category Description
Reversible Quiescence Cells like fibroblasts can re-enter the cell cycle upon stimulation by growth factors.
Terminal Differentiation Cells like cardiac myocytes or neurons exit the cycle permanently after maturation.

Final Solution: The $G_0$ (quiescent) phase is an inactive state of the cell cycle where cells exit the proliferative cycle ($G_1$ phase) due to lack of growth signals or metabolic constraints. These cells remain metabolically active but do not replicate their DNA ($S$ phase) or undergo division, essentially functioning as differentiated cells in a state of suspended animation.


More Questions from Class 11 Biology Cell Cycle and Division EXERCISES


CBSE Solutions for Class 11 Biology Cell Cycle and Division


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