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Q4:
What is $G_0$ (quiescent phase) of cell cycle?
Solution :
Theoretical Definition of the $G_0$ Phase
The $G_0$ phase, colloquially known as the quiescent phase, represents a state in which cells exit the active cell cycle (post-mitosis) and enter a period of metabolic activity without undergoing division. This state is regulated by specific extracellular signals and intracellular checkpoints [Per the Cell Cycle Regulation Model].
Step 1: Mechanism of Entry into Quiescence
Following the completion of mitosis ($M$ phase), cells enter the $G_1$ phase. If the environmental conditions—such as nutrient availability, growth factors, or cell density—are suboptimal, the cell does not pass the Restriction Point (R-point). Instead, it transitions into the $G_0$ phase. During this transition, the expression of cyclins and cyclin-dependent kinases ($CDKs$) required for the $S$ phase is downregulated [By the Retinoblastoma Protein ($pRb$) pathway].
Step 2: Physiological and Metabolic Characteristics
While the cell is not dividing, it remains biologically functional. The $G_0$ phase is characterized by the following criteria:
- Metabolic Activity: The cell maintains homeostatic functions, protein synthesis, and respiration.
- DNA Content: The DNA remains in a $2C$ state (diploid), as the cell has not yet entered the $S$ phase ($DNA$ synthesis).
- Reversibility: Depending on the cell type, this state may be permanent (e.g., neurons) or temporary (e.g., hepatocytes or lymphocytes).
Step 3: Schematic Representation of the Cell Cycle
Step 4: Comparative Analysis of Cell Fate
| Category | Description |
|---|---|
| Reversible Quiescence | Cells like fibroblasts can re-enter the cell cycle upon stimulation by growth factors. |
| Terminal Differentiation | Cells like cardiac myocytes or neurons exit the cycle permanently after maturation. |
Final Solution: The $G_0$ (quiescent) phase is an inactive state of the cell cycle where cells exit the proliferative cycle ($G_1$ phase) due to lack of growth signals or metabolic constraints. These cells remain metabolically active but do not replicate their DNA ($S$ phase) or undergo division, essentially functioning as differentiated cells in a state of suspended animation.
More Questions from Class 11 Biology Cell Cycle and Division EXERCISES
- Q1: What is the average cell cycle span for a mammalian cell?
- Q2: Distinguish cytokinesis from karyokinesis.
- Q3: Describe the events taking place during interphase.
- Q5: Why is mitosis called equational division?
- Q6(i): Name the stage of cell cycle at which one of the following events occur: (i) Chromosomes are moved to spindle equator.
- Q6(ii): Name the stage of cell cycle at which one of the following events occur: (ii) Centromere splits and chromatids separate.
- Q6(iii): Name the stage of cell cycle at which one of the following events occur: (iii) Pairing between homologous chromosomes takes place.
- Q6(iv): Name the stage of cell cycle at which one of the following events occur: (iv) Crossing over between homologous chromosomes takes place.
- Q7(a): Describe the following: (a) synapsis Draw a diagram to illustrate your answer.
- Q7(b): Describe the following: (b) bivalent Draw a diagram to illustrate your answer.
- Q7(c): Describe the following: (c) chiasmata Draw a diagram to illustrate your answer.
- Q8: How does cytokinesis in plant cells differ from that in animal cells?
- Q9: Find examples where the four daughter cells from meiosis are equal in size and where they are found unequal in size.
- Q10: Distinguish anaphase of mitosis from anaphase I of meiosis.
- Q11: List the main differences between mitosis and meiosis.
- Q12: What is the significance of meiosis?
- Q13(i): Discuss with your teacher about (i) haploid insects and lower plants where cell-division occurs, and
- Q13(ii): Discuss with your teacher about (ii) some haploid cells in higher plants where cell-division does not occur.
- Q14: Can there be mitosis without DNA replication in ‘S’ phase?
- Q15: Can there be DNA replication without cell division?
- Q16(i): Analyse the events during every stage of cell cycle and notice how the following two parameters change (i) number of chromosomes ($N$) per cell
- Q16(ii): Analyse the events during every stage of cell cycle and notice how the following two parameters change (ii) amount of DNA content ($C$) per cell
CBSE Solutions for Class 11 Biology Cell Cycle and Division
Chapters in CBSE - Class 11 Biology
- The Living World
- Biological Classification
- Plant Kingdom
- Animal Kingdom
- Morphology of Flowering Plants
- Anatomy of Flowering Plants
- Structural Organisation in Animals
- Cell – The Unit of Life
- Biomolecules
- Transport in Plants
- Mineral Nutrition
- Photosynthesis
- Respiration in Plants
- Plant Growth and Development
- Digestion and Absorption
- Breathing and Exchange of Gases
- Body Fluids and Circulation
- Excretory Products and Elimination
- Locomotion and Movement
- Neural Control and Coordination
- Chemical Coordination and Integration
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