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Q7(c):
The following are some well-known abbreviations, which have been used in this chapter. Expand each one to its full form: (c) AIDS

Solution :

Definition and Expansion

The abbreviation AIDS is the medical acronym for a specific clinical condition characterized by the progressive failure of the immune system. The expansion is as follows:

A - Acquired

I - Immuno

D - Deficiency

S - Syndrome

Clinical and Biological Context

The term is classified as a syndrome because it represents a collection of symptoms and infections resulting from specific damage to the immune system caused by the Human Immunodeficiency Virus (HIV) [Per the Biology of Retroviridae].

  • Acquired: Indicates that the condition is not hereditary or congenital, but rather contracted through specific modes of transmission (e.g., unprotected sexual contact, blood transfusion with contaminated blood, or sharing of infected needles). [Per the World Health Organization transmission guidelines].
  • Immuno: Refers to the immune system, specifically the impairment of cell-mediated immunity primarily involving $CD4^+$ T-helper lymphocytes.
  • Deficiency: Refers to the lack or insufficient functioning of the body’s natural defense mechanisms.
  • Syndrome: Denotes a group of signs and symptoms that occur together and characterize a particular abnormality or condition.

Pathophysiological Mechanism

The progression of the virus involves the infection of macrophages and helper T-lymphocytes. The virus replicates within the host cell, leading to a drastic reduction in $CD4^+$ T-cell counts, which renders the body susceptible to opportunistic infections such as Mycobacterium, viruses, fungi, and even parasites like Toxoplasma.

HIV Infection → CD4+ T-cell Depletion → AIDS Mechanism of Immune System Failure

Final Solution: The full form of the abbreviation AIDS is Acquired Immuno Deficiency Syndrome.


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