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Q3(b):
How does the transmission of each of the following diseases take place? (b) Malaria

Solution :

Biological Vector and Transmission Pathway of Malaria

Malaria is a protozoan disease caused by various species of the genus Plasmodium (e.g., P. vivax, P. malariae, P. falciparum). The transmission is strictly biological, requiring both a definitive host (the mosquito) and an intermediate host (the human).

Step 1: The Vector Mechanism

The transmission is facilitated solely by the bite of an infected female Anopheles mosquito. [Justification: The Anopheles mosquito acts as a biological vector because the pathogen, Plasmodium, completes its sexual reproduction phase within the mosquito's gut].

Step 2: Sequential Transmission Process

  • Inoculation: When an infected female Anopheles mosquito bites a healthy human, it releases sporozoites (the infectious stage of the parasite) from its salivary glands into the human bloodstream along with saliva [Mechanism: Anticoagulants in the saliva prevent blood clotting, facilitating parasite entry].
  • Systemic Migration: The sporozoites travel through the bloodstream and quickly reach the liver cells (hepatocytes).
  • Exo-erythrocytic Cycle: Within the liver, the parasites reproduce asexually (schizogony), eventually bursting the hepatocytes and releasing merozoites into the blood.
  • Erythrocytic Cycle: Merozoites invade red blood cells (RBCs). Their proliferation causes the rupture of RBCs, which is associated with the characteristic cycle of chills and high fever recurring every 3 to 4 days.

Visual Representation of Transmission Cycle

Mosquito Inoculation of Sporozoites Human Host

Summary of Epidemiological Factors

Component Description
Pathogen Plasmodium species
Vector Female Anopheles mosquito
Infectious Stage Sporozoite
Mode of Entry Bite of an infected female Anopheles (Salivary transmission)

Final Solution: The transmission of malaria occurs via the bite of an infected female Anopheles mosquito, which acts as the biological vector, injecting the infectious Plasmodium sporozoites from its salivary glands directly into the human bloodstream during a blood meal.


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