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Q3(c):
Explain the following processes: (c) Transmission of a nerve impulse across a chemical synapse

Solution :

Step 1: Structural Setup of the Chemical Synapse

A chemical synapse is a specialized junction where the terminal of a presynaptic neuron communicates with the membrane of a postsynaptic neuron. The components include:

  • Presynaptic Membrane: The membrane of the synaptic knob containing voltage-gated $Ca^{2+}$ channels.
  • Synaptic Cleft: A fluid-filled space (approximately $20\text{--}40\text{ nm}$ wide) separating the two neurons.
  • Synaptic Vesicles: Intracellular sacs containing chemical neurotransmitters (e.g., Acetylcholine).
  • Postsynaptic Membrane: The membrane of the dendrite or cell body containing specific receptor proteins.

Step 2: Depolarization and Ion Influx

When an action potential (nerve impulse) reaches the presynaptic terminal, it triggers the depolarization of the presynaptic membrane [By the Opening of Voltage-Gated Channels]. This change in membrane potential causes the voltage-gated $Ca^{2+}$ channels to open. Consequently, calcium ions ($Ca^{2+}$) flow from the extracellular fluid into the synaptic knob along their electrochemical gradient.

Step 3: Exocytosis of Neurotransmitters

The influx of $Ca^{2+}$ ions stimulates the synaptic vesicles to migrate toward and fuse with the presynaptic membrane [Mechanism: SNARE-protein mediated exocytosis]. Upon fusion, the vesicles release their neurotransmitter content into the synaptic cleft via exocytosis.

Step 4: Binding and Postsynaptic Response

The neurotransmitters diffuse across the synaptic cleft and bind to specific receptor sites present on the postsynaptic membrane. This binding opens ion channels, allowing the influx of ions that generate a new potential in the postsynaptic neuron.

Presynaptic Terminal Postsynaptic Membrane Cleft

Step 5: Nature of the Generated Potential

The resulting potential in the postsynaptic neuron may be:

Type Effect Mechanism
Excitatory Postsynaptic Potential (EPSP) Depolarization Opening of $Na^+$ channels.
Inhibitory Postsynaptic Potential (IPSP) Hyperpolarization Opening of $K^+$ or $Cl^-$ channels.

Final Solution: The transmission of a nerve impulse across a chemical synapse involves the conversion of an electrical signal (action potential) into a chemical signal (neurotransmitter release), which then triggers an electrical response in the postsynaptic cell through the activation of ligand-gated ion channels.


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