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Q2(b):
Compare the following: (b) Resting potential and action potential

Solution :

1. Conceptual Definitions

The neural membrane exhibits electrical polarity due to the unequal distribution of ions across the phospholipid bilayer, maintained by active transport and selective permeability. The comparison between the resting state and the active state is fundamental to understanding signal propagation.

2. Comparative Data Analysis

Feature Resting Potential Action Potential
Definition The membrane potential of a neuron at rest. A rapid, temporary change in membrane potential.
Typical Value $-70\text{ mV}$ (approximate). $+30\text{ to } +40\text{ mV}$ (peak).
Ion Permeability High $K^+$ permeability; low $Na^+$ permeability. High $Na^+$ permeability (depolarization); high $K^+$ permeability (repolarization).
Active Mechanism $Na^+/K^+$ pump maintains steady state. Voltage-gated $Na^+$ and $K^+$ channels regulate flux.

3. Physiological Progression

  • Resting Membrane Potential (RMP): The interior of the axolemma is electronegative relative to the extracellular fluid. This state is maintained by the $Na^+/K^+$-ATPase pump, which transports $3\text{ }Na^+$ ions out for every $2\text{ }K^+$ ions moved in [Per the Electrogenic Pump Principle].
  • Depolarization: Upon stimulation, voltage-gated $Na^+$ channels open. $Na^+$ ions rush into the intracellular space down their electrochemical gradient, causing the membrane potential to shift from $-70\text{ mV}$ towards a positive value [By the Law of Diffusion].
  • Repolarization: Shortly after the peak, $Na^+$ channels inactivate, and voltage-gated $K^+$ channels open. The efflux of $K^+$ restores the negative internal charge, eventually returning the cell to the RMP state [Per the Repolarization Kinetics].

4. Graphical Visualization of Membrane Potential Changes

$-70\text{mV}$ $+30\text{mV}$ Action Potential Time (ms)

5. Conclusion

The resting potential represents a state of polarized preparedness, while the action potential represents a transient reversal of this polarization, facilitating the transmission of nerve impulses along the axon.

Final Solution: The resting potential is a stable negative state ($-70\text{ mV}$) maintained by the $Na^+/K^+$ pump, whereas the action potential is an excitable, rapid reversal of charge triggered by the influx of $Na^+$ ions through voltage-gated channels.


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