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Q9:
Suggest some methods to assist infertile couples to have children.

Solution :

Techniques of Assisted Reproductive Technology (ART)

Infertility, defined as the inability to produce children in spite of unprotected sexual cohabitation, necessitates medical intervention through Assisted Reproductive Technologies (ART). The following table summarizes the methodologies employed to assist infertile couples:

Technique Full Form Mechanism of Action
IVF In Vitro Fertilization Fertilization occurs outside the body in laboratory conditions, followed by embryo transfer.
ZIFT Zygote Intra-Fallopian Transfer Zygotes or early embryos (up to 8 blastomeres) are transferred into the fallopian tube.
IUT Intra-Uterine Transfer Embryos with more than 8 blastomeres are transferred into the uterus.
GIFT Gamete Intra-Fallopian Transfer Transfer of an ovum collected from a donor into the fallopian tube of another female who cannot produce one.
ICSI Intra Cytoplasmic Sperm Injection A sperm is directly injected into the ovum in the laboratory.
AI Artificial Insemination Semen collected from the husband or donor is artificially introduced into the vagina or uterus.

Step 1: Extracorporeal Fertilization (IVF-ET)

In cases where the female cannot produce ova or the male has a low sperm count, In Vitro Fertilization is performed. [Per the clinical protocol of ART], ova from the wife/donor and sperms from the husband/donor are fused to form a zygote. This simulates the physiological environment of the ampullary region of the fallopian tube.

Step 2: Embryo Transfer Procedures (ZIFT vs. IUT)

The placement of the embryo is determined by its developmental stage:

  • ZIFT: When the embryo is at the 8-blastomere stage, it is placed in the fallopian tube [By anatomical requirement for tubal progression].
  • IUT: When the embryo reaches the morula or blastocyst stage, it is placed in the uterus to ensure successful implantation [Per the biological requirement for endometrial attachment].

Step 3: Gamete and Sperm Manipulation

If the female is unable to provide the ovum but can support the fetus, GIFT is utilized. Conversely, for male-factor infertility (such as oligospermia), ICSI is the gold standard, where the sperm is manually bypasses the zona pellucida of the oocyte using a micromanipulator.

Visual Representation of Fertilization Site

Fertilization (IVF) Lab Environment

Step 4: Artificial Insemination (AI)

In cases where the male partner has inability to inseminate or a very low sperm count, artificial insemination (AI) or Intra-uterine insemination (IUI) is performed [Per clinical necessity]. The semen is collected, processed in a lab to concentrate the sperm, and introduced directly into the female reproductive tract.

Final Solution: The primary methods to assist infertile couples include IVF-ET (involving ZIFT and IUT), GIFT, ICSI, and Artificial Insemination, all of which are categorized under Assisted Reproductive Technologies (ART).


More Questions from Class 12 Biology Reproductive Health EXERCISES


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