Find the best tutors and institutes for Class 12 Tuition

Find Best Class 12 Tuition

Please select a Category.

Please select a Locality.

No matching category found.

No matching Locality found.

Outside India?

What is Sickle-cell haemoglobin?

Durgapada Rana
07/05/2018 0 0

HbS forms as a result of a single amino acid substitution in the β-chain of Hb. Replacement of the glutamate residue at position 6 in the β-chain by a valine residue is the only chemical difference between HbA and sickle-cell haemoglobin. The residue is present on the outer surface of the molecule. The change produces a sticky hydrophobic spot on the surface that results in the abnormal quaternary association of haemoglobin. This makes the deoxyHbS less soluble than deoxyHbA. Insoluble deoxyHbS forms polymers that aggregate into tubular fibres. The formation of insoluble deoxyHbS fibres distorts the RBC into the elongated sickle-shaped structure which is characteristic of the disease, sickle-cell anaemia. Sickle-cell anaemia and sickle-cell trait are different. Sickle-cell describes a condition in which an individual has one abnormal allele of the β-globin gene(heterozygous). A person with sickle-cell anaemia has two copies of the abnormal β-globin gene(homozygous).

0 Dislike
Follow 4

Please Enter a comment


Other Lessons for You

The site of Photosynthesis:- NEET/AIIMS/JIPMER
The site of Photosynthesis Photosynthesis takes place in Mesophyll cells inside chloroplasts. It is a process which involves chemical reactions in which water and carbon dioxide are converted into energy...

Anmol Sharma | 6 days ago

0 0

How to remember the nature of 12 pairs of cranial nerves?
Trick- Some Says Money Matters But My Brother Says Big Books Matter Most. Now know the initial letter of each word written in capital. And decode them as S stands for sensory, B stands for both(mixed)...

Monalisha M. | 29 Aug

0 0

Hi, We all know that only GOD possesses the power of creation, maintenance, and destruction but do you know that there is an enzyme which possesses power similar to GOD (i.e. creation, maintenance, and...

Biju G. | 28 Aug

0 0

Cell membrane
One of the most impressive structures to be studied. Given by Singer & Nicholson, a membrane is double lipid layer where lipids are present almost running parallel in the cell circumference. In...

Private, Public and Joint Sector Enterprises-Class 11 NCERT, Class 9 ICSE,Commercial Studies
CBSE Std XIth Business Studies Classification of Commercial Organisations based on the ownership-

Rajiv Vadera | 01 Jul

0 0

Find Best Class 12 Tuition ?

Find Now » is India's largest network of most trusted tutors and institutes. Over 25 lakh students rely on, to fulfill their learning requirements across 1,000+ categories. Using, parents, and students can compare multiple Tutors and Institutes and choose the one that best suits their requirements. More than 6.5 lakh verified Tutors and Institutes are helping millions of students every day and growing their tutoring business on Whether you are looking for a tutor to learn mathematics, a German language trainer to brush up your German language skills or an institute to upgrade your IT skills, we have got the best selection of Tutors and Training Institutes for you. Read more