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Q12:
Define a cardiac cycle and the cardiac output.

Solution :

1. Definition of the Cardiac Cycle

The cardiac cycle is defined as the complete sequence of coordinated electrical, mechanical, and pressure-related events that occur in the heart from the beginning of one heartbeat to the beginning of the next. In a healthy adult human heart beating at an average rate of $72$ beats per minute, the cycle duration is approximately $0.8$ seconds.

The process is divided into two primary phases based on the state of the cardiac musculature [Per Physiological Standard Nomenclature]:

  • Atrial Systole: The contraction of the atria, forcing the remaining blood into the ventricles (lasting $\approx 0.1$ seconds).
  • Ventricular Systole: The contraction of the ventricles, ejecting blood into the pulmonary artery and the aorta (lasting $\approx 0.3$ seconds).
  • Joint Diastole: The state of relaxation where all four chambers are in a relaxed state, allowing for passive filling (lasting $\approx 0.4$ seconds).

2. Definition of Cardiac Output

Cardiac Output ($CO$) is defined as the total volume of blood pumped by each ventricle into the systemic or pulmonary circulation per minute. It is a critical indicator of cardiovascular performance and systemic perfusion.

The mathematical derivation is expressed as:

$CO = SV \times HR$

Where:

  • $SV$ (Stroke Volume): The volume of blood pumped out by each ventricle during a single cardiac cycle. An average value is $\approx 70\text{ mL}$.
  • $HR$ (Heart Rate): The number of cardiac cycles occurring per minute. An average value is $\approx 72\text{ beats/min}$.

3. Mathematical Calculation & Analysis

Using the standard physiological constants:

$SV = 70\text{ mL/beat}$

$HR = 72\text{ beats/min}$

$CO = 70\text{ mL/beat} \times 72\text{ beats/min} = 5040\text{ mL/min}$

Conversion to Liters: $CO \approx 5.04\text{ L/min}$ [By the standard unit conversion $1000\text{ mL} = 1\text{ L}$].

4. Visual Representation of Cardiac Cycle Phases

Atrial Sys Ventricular Sys Joint Diastole Time (0.8s Total)

Final Solution: The Cardiac Cycle is the sequential electrical and mechanical event of one heartbeat, typically lasting 0.8 seconds. Cardiac Output is the volume of blood pumped by the ventricles per minute, calculated as the product of Stroke Volume and Heart Rate, averaging approximately 5 liters per minute in a healthy adult.


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