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Q5:
In which way have microbes played a major role in controlling diseases caused by harmful bacteria?
Solution :
Step 1: Identification of Therapeutic Agents
Microbes, primarily fungi and certain bacteria, serve as the primary source for the production of antibiotics. Antibiotics are chemical substances produced by microorganisms which, in low concentrations, can kill or retard the growth of other disease-causing microorganisms [Per Waksman’s definition of antibiotics].
Step 2: Mechanism of Action Against Pathogenic Bacteria
The microbial products function through various biochemical pathways to inhibit bacterial proliferation:
- Inhibition of Cell Wall Synthesis: Antibiotics like Penicillin interfere with the synthesis of peptidoglycan, leading to osmotic lysis of the bacterial cell.
- Protein Synthesis Inhibition: Agents like Streptomycin and Tetracycline bind to the $70S$ bacterial ribosomes, preventing the translation of bacterial mRNA into functional proteins.
- Nucleic Acid Synthesis Interference: Certain antibiotics inhibit DNA gyrase or RNA polymerase, halting bacterial replication.
Step 3: Key Examples and Sources
| Antibiotic | Microbial Source | Target Pathogen Type |
|---|---|---|
| Penicillin | Penicillium notatum (Fungus) | Gram-positive bacteria |
| Streptomycin | Streptomyces griseus (Actinobacteria) | Gram-negative bacteria (e.g., Mycobacterium tuberculosis) |
| Bacitracin | Bacillus subtilis (Bacteria) | Various bacterial strains |
Step 4: Role in Modern Medicine
Microbes have transformed the treatment of once-fatal bacterial infections. By identifying these antimicrobial compounds, medical science can now manage diseases such as:
- Plague: Controlled via Streptomycin.
- Whooping Cough (Kali Khansi): Managed through targeted antibiotic intervention.
- Diphtheria (Gal ghotu): Effectively treated using microbial-derived antitoxins and antibiotics.
Step 5: Visual Representation of Antibiotic Inhibition
Final Solution: Microbes play a major role in controlling bacterial diseases primarily through the production of antibiotics—secondary metabolites that possess the biochemical capacity to specifically target and disrupt essential bacterial life processes such as cell wall biosynthesis, protein synthesis, and DNA replication, thereby eradicating or inhibiting the pathogens responsible for severe human ailments.
More Questions from Class 12 Biology Microbes in Human Welfare EXERCISES
- Q1: Bacteria cannot be seen with the naked eyes, but these can be seen with the help of a microscope. If you have to carry a sample from your home to your biology laboratory to demonstrate the presence of microbes with the help of a microscope, which sample would you carry and why?
- Q1: Bacteria cannot be seen with the naked eyes, but these can be seen with the help of a microscope. If you have to carry a sample from your home to your biology laboratory to demonstrate the presence of microbes with the help of a microscope, which sample would you carry and why?
- Q2: Give examples to prove that microbes release gases during metabolism.
- Q2: Give examples to prove that microbes release gases during metabolism.
- Q3: In which food would you find lactic acid bacteria? Mention some of their useful applications.
- Q3: In which food would you find lactic acid bacteria? Mention some of their useful applications.
- Q4: Name some traditional Indian foods made of wheat, rice and Bengal gram (or their products) which involve use of microbes.
- Q4: Name some traditional Indian foods made of wheat, rice and Bengal gram (or their products) which involve use of microbes.
- Q5: In which way have microbes played a major role in controlling diseases caused by harmful bacteria?
- Q6: Name any two species of fungus, which are used in the production of the antibiotics.
- Q6: Name any two species of fungus, which are used in the production of the antibiotics.
- Q7: What is sewage? In which way can sewage be harmful to us?
- Q7: What is sewage? In which way can sewage be harmful to us?
- Q8: What is the key difference between primary and secondary sewage treatment?
- Q8: What is the key difference between primary and secondary sewage treatment?
- Q9: Do you think microbes can also be used as source of energy? If yes, how?
- Q9: Do you think microbes can also be used as source of energy? If yes, how?
- Q10: Microbes can be used to decrease the use of chemical fertilisers and pesticides. Explain how this can be accomplished.
- Q10: Microbes can be used to decrease the use of chemical fertilisers and pesticides. Explain how this can be accomplished.
- Q11: Three water samples namely river water, untreated sewage water and secondary effluent discharged from a sewage treatment plant were subjected to BOD test. The samples were labelled \(A\), \(B\) and \(C\); but the laboratory attendant did not note which was which. The BOD values of the three samples \(A\), \(B\) and \(C\) were recorded as 20mg/L, 8mg/L and 400mg/L, respectively. Which sample of the water is most polluted? Can you assign the correct label to each assuming the river water is relatively clean?
- Q11: Three water samples namely river water, untreated sewage water and secondary effluent discharged from a sewage treatment plant were subjected to BOD test. The samples were labelled (A), (B) and (C); but the laboratory attendant did not note which was which. The BOD values of the three samples (A), (B) and (C) were recorded as (20mg/L), (8mg/L) and (400mg/L), respectively. Which sample of the water is most polluted? Can you assign the correct label to each assuming the river water is relatively clean?
- Q12: Find out the name of the microbes from which Cyclosporin \(A\) (an immunosuppressive drug) and Statins (blood cholesterol lowering agents) are obtained.
- Q12: Find out the name of the microbes from which Cyclosporin (A) (an immunosuppressive drug) and Statins (blood cholesterol lowering agents) are obtained.
- Q13(a): Find out the role of microbes in the following and discuss it with your teacher. (a) Single cell protein (SCP)
- Q13(a): Find out the role of microbes in the following and discuss it with your teacher. (a) Single cell protein (SCP)
- Q13(b): Find out the role of microbes in the following and discuss it with your teacher. (b) Soil
- Q13(b): Find out the role of microbes in the following and discuss it with your teacher. (b) Soil
- Q14: Arrange the following in the decreasing order (most important first) of their importance, for the welfare of human society. Give reasons for your answer. Biogas, Citric acid, Penicillin and Curd
- Q14: Arrange the following in the decreasing order (most important first) of their importance, for the welfare of human society. Give reasons for your answer. Biogas, Citric acid, Penicillin and Curd
- Q15: How do biofertilisers enrich the fertility of the soil?
- Q15: How do biofertilisers enrich the fertility of the soil?
CBSE Solutions for Class 12 Biology Microbes in Human Welfare
Chapters in CBSE - Class 12 Biology
- Reproduction in Organisms
- Human Reproduction
- Reproductive Health
- Principles of Inheritance and Variation
- Molecular Basis of Inheritance
- Evolution
- Human Health and Disease
- Strategies for Enhancement in Food Production
- Biotechnology: Principles and Processes
- Biotechnology and Its Applications
- Organisms and Populations
- Ecosystem
- Biodiversity and Conservation
- Environmental Issues
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