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Why is it not possible for an alien DNA to become part of a chromosome anywhere along its length and replicate normally? 

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It's not possible for alien DNA to become part of a chromosome anywhere along its length and replicate normally because the cellular machinery and regulatory mechanisms of the host organism are highly specific to its own DNA. Alien DNA would not be recognized properly and integrated into the host gen...
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It's not possible for alien DNA to become part of a chromosome anywhere along its length and replicate normally because the cellular machinery and regulatory mechanisms of the host organism are highly specific to its own DNA. Alien DNA would not be recognized properly and integrated into the host genome.

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