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Males afflicted with Kartagener’s syndrome are sterile because of immotile sperm, and they tend to suffer from lung infections. This disorder has a genetic basis. Suggest what the underlying defect might be.

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Kartagener syndrome is a subset of primary ciliary dyskinesia, an autosomal recessive condition characterized by abnormal ciliary structure and/or function leading impaired mucociliary clearance. The prevalence of primary ciliary dyskinesia is approximately 1/12000-1/60000.5 Approximately 50% of patient...
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Kartagener syndrome is a subset of primary ciliary dyskinesia, an autosomal recessive condition characterized by abnormal ciliary structure and/or function leading impaired mucociliary clearance. The prevalence of primary ciliary dyskinesia is approximately 1/12000-1/60000.5 Approximately 50% of patient with primary ciliary dyskinesia have Kartagener syndrome/situs abnormality. No gender predilection is recognized. Kartagener syndrome is characterised by the clinical triad of 1: situs inversus chronic sinusitis and/or nasal polyposis bronchiectasis Other features include : telecanthus - widened interpupillary distance by a nasal polyp Infertility in male subfertility in female. CT tends to demonstrate bronchiectasis which may be variable in severity. However, changes are much milder than in cystic fibrosis4. The morphology of bronchiectasis can be tubular/cylindrical or saccular/cystic. In addition, CT demonstrates: consolidation mucocele, impacted mucus in bronchioles. tree-in-bud pattern or centrilobular nodules maybe encountered with mucus impaction and endobronchial spread of infection mosaic perfusion/ air trapping as ancillary findings eventual scarring may result from recurrent infection, requiring pulmonary resection surgery Situs abnormality with associated lower lobe bronchiectasis should prompt the diagnosis of Kartagener syndrome. However, there is a differential: hereditary impaired mucociliary clearance cystic fibrosis Young syndrome impaired immunity primary immunodeficiency syndrome acquired immunodeficiency (AIDS) hypersensitivity and immune reaction ABPA graft versus host disease. read less
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post-graduate in pediatrics

Ultrastructural defect in cilia, Autosomal recessive, defect in long arm of chromosome 15.
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M.Sc. (Botany).B.Ed.

Immotile cilia syndrome (ICS) is an autosomal recessive disease with extensive genetic heterogeneity characterized by abnormal ciliary motion and impaired mucociliary clearance. Ultrastructural and functional defects of cilia result in the lack of effective ciliary motility, causing abnormal mucociliary...
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Immotile cilia syndrome (ICS) is an autosomal recessive disease with extensive genetic heterogeneity characterized by abnormal ciliary motion and impaired mucociliary clearance. Ultrastructural and functional defects of cilia result in the lack of effective ciliary motility, causing abnormal mucociliary clearance. This leads to recurrent or persistent respiratory infections, sinusitis, otitis media, and male infertility. In 50% of the patients, ICS is associated with situs inversus. read less
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sinuses, eustachian tube, fallopian tube, as well as in the flagella of sperm, so lung infection & male sterility occurs.
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Math Educator for Std.11th ,12th , Engineering Entrance and Degree Level with 11+ Years Experience

Kartagener syndrome is a rare hereditary disease caused by a gene defect. The defect is considered to be “autosomal recessive.” This means that an individual must inherit the gene from both parents in order to be affected. This condition causes abnormalities of the respiratory tract. It also causes...
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Kartagener syndrome is a rare hereditary disease caused by a gene defect. The defect is considered to be “autosomal recessive.” This means that an individual must inherit the gene from both parents in order to be affected. This condition causes abnormalities of the respiratory tract. It also causes transposition of the organs. An estimated one in 30,000 people are born with Kartagener syndrome. It is marked by the presence of two distinct abnormalities: primary ciliary dyskinesia and situs inversus. Kartagener syndrome is caused by a mutation in the DNAI1 gene, which makes a cellular protein required for normal functioning cilia (cilia line the respiratory tract) and sperm motility. read less
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biology

Kartagener syndrome is a recessive autosomal disease. Caused by gene defect. Causes defects in cilia lining the respiratory tract, sinuses, eustachian tube, fallopian tube, as well as in the flagella of sperm, so lung infection & male sterility occurs.
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